Discussion: An estimate of the science-wise false discovery rate and application to the top medical literature.

نویسنده

  • Steven N Goodman
چکیده

BEM, D. J. (2011). Feeling the future: experimental evidence for anomalous retroactive influences on cognition and affect. Journal of Personality and Social Psychology 100, 407–425. EFRON, B. AND TIBSHIRANI, R. (2002). Empirical Bayes methods and false discovery rates for microarrays. Genetic Epidemiology 23, 70–86. FRANCIS, G. (2012). Too good to be true: publication bias in two prominent studies from experimental psychology. Psychonomic Bulletin and Review 19, 151–156. FRENCH, C. (2012). Precognition Studies and the Curse of the Failed Replications. Guardian newspaper, 15 March. http://www.guardian.co.uk/science/2012/mar/15/precognition-studies-curse-failed-replications. GARCIA-BERTHOU, E. AND ALCARAZ, C. (2004). Incongruence between test statistics and P values in medical papers. BMC Medical Research Methodology 4(1), 13. GELMAN, A. AND WEAKLIEM, D. (2009). Of beauty, sex, and power: statistical challenges in estimating small effects. American Scientist 97, 310–316. GREENLAND, S. (2005). Multiple-bias modelling for analysis of observational data. Journal of the Royal Statistical Society A 168, 267–306. IOANNIDIS, J. (2005). Why most published research findings are false. PLOS Medicine 2(8), e124. MARCUS, A. AND ORANSKY, I. (2010–2013). Retraction Watch Blog. http://retractionwatch.wordpress.com. ROSENBAUM, P. R. (2010). Observational Studies, 2nd edition. New York: Springer. SIMMONS, J., NELSON L. AND SIMONSOHN U. (2011). False-positive psychology: undisclosed flexibility in data collection and analysis allow presenting anything as significant. Psychological Science 22, 1359–1366. STRASAK, A. M., ZAMAN, Q., MARINELL, G., PFEIFFER, K. P. AND ULMER, H. (2007). The use of statistics in medical research. American Statistician 61, 47–55. YARKONI, T. (2011). The Psychology of Parapsychology, or Why Good Researchers Publishing Good Articles in Good Journals Can Still Get it Totally Wrong. Citation Needed blog, 10 January. http://www.talyarkoni.org/ blog/2011/01/10/the-psychology-of-parapsychology-or-why-good-researchers-publishing-good-articles-in-goodjournals-can-still-get-it-totally-wrong.

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An estimate of the science-wise false discovery rate and application to the top medical literature.

The accuracy of published medical research is critical for scientists, physicians and patients who rely on these results. However, the fundamental belief in the medical literature was called into serious question by a paper suggesting that most published medical research is false. Here we adapt estimation methods from the genomics community to the problem of estimating the rate of false discove...

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عنوان ژورنال:
  • Biostatistics

دوره 15 1  شماره 

صفحات  -

تاریخ انتشار 2014