Discussion: An estimate of the science-wise false discovery rate and application to the top medical literature.
نویسنده
چکیده
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منابع مشابه
An estimate of the science-wise false discovery rate and application to the top medical literature.
The accuracy of published medical research is critical for scientists, physicians and patients who rely on these results. However, the fundamental belief in the medical literature was called into serious question by a paper suggesting that most published medical research is false. Here we adapt estimation methods from the genomics community to the problem of estimating the rate of false discove...
متن کاملDiscussion: An estimate of the science-wise false discovery rate and applications to top medical journals by Jager and Leek.
The original paper by Ioannidis (2005) has done much to raise the awareness to the possible sources of biases in current scientific work. However, Ioannidis described what may be happening in the scientific literature if scientists use blindly the marginal 0.05 significance level rule throughout their work. From this possibility, he reached the alarming conclusion that most research findings ar...
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Background and Objectives: In recent years, new technologies have led to produce a large amount of data and in the field of biology, microarray technology has also dramatically developed. Meanwhile, the Fisher test is used to compare the control group with two or more experimental groups and also to detect the differentially expressed genes. In this study, the false discovery rate was investiga...
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متن کاملProtein-Protein Interaction Analysis of Common Top Genes in Obsessive-Compulsive disorder (OCD) and Schizophrenia: Towards New Drug Approach
Comorbidty is common among psychiatric disorders including obsessive-compulsive disorder and schizophrenia with a high rate. Many studies suggested that the disorders may have same etiological bases. In this regard, shared pathways of glutamate, dopaminergic, and serotonin are the known ones. Here, the common significant genes are examined to understand the possible molecular origin of the diso...
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ورودعنوان ژورنال:
- Biostatistics
دوره 15 1 شماره
صفحات -
تاریخ انتشار 2014